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Neurodegenerative diseases such as Alzheimer’s are associated with the aggregation of endogenous peptides and proteins that contribute to neuronal dysfunction and loss. The glymphatic system, a brai ...


Gene therapy for Leber congenital amaurosis ( LCA ), an inherited disorder that causes vision loss starting in childhood, improved patients’ eyesight and the sensitivity of the retina within weeks of ...


Using brain tumor samples collected from children in the United States and Europe, a team of researchers found that the drug Panobinostat ( Farydak ) and similar gene regulating drugs may be effective ...


PARP-1 and PARP-2 are nuclear enzymes activated by DNA strand breaks and are involved in recruitment of DNA repair proteins to sites of damage. PARP-1 and PARP-2 share partially overlapping functions, ...


Lung cancer is the number one cause of cancer mortality globally and has an estimated incidence of 1.3 million new cases every year. Approximately 80–85% of the newly diagnosed cases of lung cancer ar ...


Immune checkpoint inhibitors are effective cancer treatments, but molecular determinants of clinical benefit are unknown. Ipilimumab ( Yervoy ) and Tremelimumab are antibodies against cytotoxic T-lymp ...


Therapies that target the programmed death-1 ( PD-1 ) receptor have shown unprecedented rates of durable clinical responses in patients with various cancer types. One mechanism by which cancer tissues ...


Patients with multiple sclerosis were able to safely tolerate treatment with cells cultured from human placental tissue, according to a study published in the journal Multiple Sclerosis and Related Di ...


A previously unknown mechanism through which the brain produces new nerve cells after a stroke has been discovered at Lund University and Karolinska Institutet in Sweden. The findings have been publ ...


Traumatic brain injury ( TBI ) is a major cause of death and long-term disability worldwide. To date, there are no effective pharmacological treatments for traumatic brain injury. Recombinant huma ...


GP2 is a HER2 derived, HLA-A2+-restricted immunogenic peptide designed to stimulate CD8+T cells to recognize tumor cells with any level of HER2 expression ( IHC 1-3+ ). Accrual to a prospective, rando ...


Alopecia areata is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in alopecia areata are not defined ...


Metformin ( Glucophage ) is a first-line oral agent used in the treatment of type 2 diabetes mellitus, but glycaemic response to this drug is highly variable. Understanding the genetic contribution ...


Breast cancer is characterised by genomic alterations. Researchers did a multicentre molecular screening study to identify abnormalities in individual patients with the aim of providing targeted thera ...


A genomic trial has unmasked 108 chromosomal sites harboring inherited variations in the genetic code linked to schizophrenia, 83 of which had not been previously reported. By combining data from all ...


The majority of non-small cell lung cancer ( NSCLC ) patients harbor EGFR-activating mutations that can be therapeutically targeted by EGFR tyrosine kinase inhibitors ( EGFR-TKI ), such as Erlotinib ( ...


In 2008, the first transplantation of a tissue-engineered trachea in a human being was done to replace an end-staged left main bronchus with malacia in a 30-year-old woman. Researchers have reported ...


CCR5 is the major coreceptor for human immunodeficiency virus ( HIV ). Researchers have investigated whether site-specific modification of the gene ( gene editing ), in this case, the infusion of auto ...


Researchers from Memorial Sloan Kettering Cancer Center have reported more encouraging news about one of the most exciting methods of cancer treatment today. The largest clinical study ever conducted ...


Researchers at the University of Illinois at Chicago have developed a system for precisely delivering anti-inflammatory drugs to immune cells gone out of control, while sparing their well-behaved coun ...


The immune system wages an internal battle every day to protect people against a broad range of infections. However, researchers have found that the immune response can sometimes make us vulnerable to ...


Previous studies have demonstrated that less-differentiated T cells are ideal for adoptive T cell transfer therapy ( ACT ) and that fibronectin CH296 ( FN-CH296 ) together with anti-CD3 resulted in cu ...


Several organs, including the lungs and kidneys, are formed by epithelial tubes whose proper morphogenesis ensures correct function. This is best exemplified by the kidney, where defective establishme ...


Hypertension and chronic kidney disease ( CKD ) are complex traits representing major global health problems. Multiple genome-wide association studies have identified common variants in the promoter o ...


In humans, mutations in the gene encoding for forkhead box P3 ( FOXP3 ), a critically important transcription factor for CD4+CD25+ regulatory T ( Treg ) cell function, lead to a life-threatening syste ...


The immune system is composed of numerous interacting cell populations with distinct functions. As for any system, it is ( it has to be ) tightly regulated. Failure of regulation leads notably to infl ...


Recessive dystrophic epidermolysis bullosa ( RDEB ) results from deficiency of type VII collagen ( C7 ), which results in lack of attachment between the epidermis and dermis, severe blistering, and a ...


The Committee for Medicinal Products for Human Use ( CHMP ) has recommended marketing authorisation for Maci ( matrix-induced autologous chondrocyte implantation ), an advanced-therapy medicinal produ ...


A study has identified a previously unrecognized mutation that causes an inherited form of amyotrophic lateral sclerosis ( ALS ). The research, published in the journal Neuron, implicates defects in ...


Genetic variations in the Sonic Hedgehog pathway increase the likelihood of recurrence, reduce survival time and limit response to therapy for people with non-muscle invasive bladder cancer.These vari ...


The first operation for transplantation of a tissue-engineered airway has been successful, and has massively improved the quality of life of the 30-year-old Colombian female recipient, a mother of two ...


The FDA ( Food and Drug Administration ) has approved a drug to help ease the suffering faced by those with certain chronic inflammatory diseases. Arcalyst ( Rilonacept, an Interleukin-1 blocker ) is ...


A gene therapy treatment that restores a missing liver enzyme in test animals could provide a cure for a rare metabolic disorder in humans. People born with the disorder, called glycogen storage ...


Immune cells that would normally die in healthy people accumulate in bodies of patients who have lupus and contribute to the disease, according to new research published in the Immunity. The findin ...


A rare disorder caused by an excess of two types of immune cells, the mast cell found in various tissues and its blood-based twin, the basophil, has successfully been treated with a cancer drug, repor ...


The endocannabinoid system was discovered through research into delta 9-tetrahydrocannabinol ( 9-THC ), the active ingredient in cannabis. The endocannabinoid system consists of cannabinoid recepto ...


A Glucosamine-like dietary supplement has been found to suppress the damaging autoimmune response seen in multiple sclerosis and type-1 diabetes mellitus, according to University of California, Irvin ...


Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have discovered new molecular evidence of the role of the hormone prolactin in breast cancer. They have found that prolactin, a pi ...


Not all patients with sepsis mount the same immune response, even when they look the same clinically, according to findings from the first large-scale natural history study of sepsis. The results, pub ...


Researchers at the Massachusetts General Hospital ( MGH ) Cancer Center have discovered a novel gene mutation associated with Wilms tumor, the most common pediatric kidney cancer. The newly identifi ...


A large-scale genomic study has uncovered new genetic variations associated with multiple sclerosis, findings that suggest a possible link between multiple sclerosis and other autoimmune diseases. T ...


Using a novel three-part screening process, researchers at Dana-Farber Cancer Institute have identified a gene that is made inappropriately in about a third of all breast cancers. The discovery, reach ...


The FDA ( Food and Drug Administration ) has approved Soliris ( Eculizumab ). Soliris is the first therapy approved for paroxysmal nocturnal hemoglobinuria ( PNH ), a rare, disabling and life-threate ...


Drugs known as beta blockers help slow nerve impulses traveling through the heart in order to reduce the heart's workload. This effect is achieved via their action on beta-adrenergic receptors present ...


A team led by Duke University Medical Center researchers has identified in yeast a molecular "brake" that could inhibit the proliferation of cells that characterizes neurofibromatosis 1, a common here ...


Researchers at Mayo Clinic have uncovered a new cellular secret that may explain how certain cancers spread. If the mechanism that drives cancer movement, also called metastasis, can be understood we ...


Researchers at Mayo Clinic have identified and characterized an important signal used by the human immune system to help destroy tumors. When this signal is generated inside cells called natural kille ...


Disruption of a single gene, Nrf2, plays a critical role in regulating the body's innate immune response to sepsis and septic shock. A research team, led by Shyam Biswal, at the Johns Hopkins Bloo ...


Selective T cell stimulation could help improve treatment of autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or juvenile diabetes. and cancer. " Our study shows that different ...


Researchers from the University of Alberta, the Yerkes National Primate Research Center of Emory University and the Emory Transplant Center has successfully transplanted insulin-producing neonatal por ...



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