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A previously unknown mechanism through which the brain produces new nerve cells after a stroke has been discovered at Lund University and Karolinska Institutet in Sweden. The findings have been publ ...


Traumatic brain injury ( TBI ) is a major cause of death and long-term disability worldwide. To date, there are no effective pharmacological treatments for traumatic brain injury. Recombinant huma ...


GP2 is a HER2 derived, HLA-A2+-restricted immunogenic peptide designed to stimulate CD8+T cells to recognize tumor cells with any level of HER2 expression ( IHC 1-3+ ). Accrual to a prospective, rando ...


Alopecia areata is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in alopecia areata are not defined ...


Metformin ( Glucophage ) is a first-line oral agent used in the treatment of type 2 diabetes mellitus, but glycaemic response to this drug is highly variable. Understanding the genetic contribution ...


Breast cancer is characterised by genomic alterations. Researchers did a multicentre molecular screening study to identify abnormalities in individual patients with the aim of providing targeted thera ...


A genomic trial has unmasked 108 chromosomal sites harboring inherited variations in the genetic code linked to schizophrenia, 83 of which had not been previously reported. By combining data from all ...


The majority of non-small cell lung cancer ( NSCLC ) patients harbor EGFR-activating mutations that can be therapeutically targeted by EGFR tyrosine kinase inhibitors ( EGFR-TKI ), such as Erlotinib ( ...


In 2008, the first transplantation of a tissue-engineered trachea in a human being was done to replace an end-staged left main bronchus with malacia in a 30-year-old woman. Researchers have reported ...


CCR5 is the major coreceptor for human immunodeficiency virus ( HIV ). Researchers have investigated whether site-specific modification of the gene ( gene editing ), in this case, the infusion of auto ...


Researchers from Memorial Sloan Kettering Cancer Center have reported more encouraging news about one of the most exciting methods of cancer treatment today. The largest clinical study ever conducted ...


Researchers at the University of Illinois at Chicago have developed a system for precisely delivering anti-inflammatory drugs to immune cells gone out of control, while sparing their well-behaved coun ...


The immune system wages an internal battle every day to protect people against a broad range of infections. However, researchers have found that the immune response can sometimes make us vulnerable to ...


Previous studies have demonstrated that less-differentiated T cells are ideal for adoptive T cell transfer therapy ( ACT ) and that fibronectin CH296 ( FN-CH296 ) together with anti-CD3 resulted in cu ...


Several organs, including the lungs and kidneys, are formed by epithelial tubes whose proper morphogenesis ensures correct function. This is best exemplified by the kidney, where defective establishme ...


Hypertension and chronic kidney disease ( CKD ) are complex traits representing major global health problems. Multiple genome-wide association studies have identified common variants in the promoter o ...


In humans, mutations in the gene encoding for forkhead box P3 ( FOXP3 ), a critically important transcription factor for CD4+CD25+ regulatory T ( Treg ) cell function, lead to a life-threatening syste ...


The immune system is composed of numerous interacting cell populations with distinct functions. As for any system, it is ( it has to be ) tightly regulated. Failure of regulation leads notably to infl ...


Recessive dystrophic epidermolysis bullosa ( RDEB ) results from deficiency of type VII collagen ( C7 ), which results in lack of attachment between the epidermis and dermis, severe blistering, and a ...


The Committee for Medicinal Products for Human Use ( CHMP ) has recommended marketing authorisation for Maci ( matrix-induced autologous chondrocyte implantation ), an advanced-therapy medicinal produ ...



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